Prof Dr Patrick Segers
Afilliation
Faculty of Engineering and Architecture
Institute Biomedical Technology (IBiTech)
Biofluid, Tissue and Solid Mechanics for Medical Applications
Department of Electronics and Information Systems
Research focus
Patrick Segers heads the bioMMeda research unit (“Biofluid, tissue and solid mechanics for medical applications”) within the Institute Biomedical Technology (IBiTech) at Ghent University. The research of the group is rather applied but always relates to fluid mechanics/tissue mechanics and mass transport aspects of the (patho)physiology of an organ system. The focus of the research can be an improved understanding of the (patho)physiology of an organ system (e.g. lymphatic edema, hypertension, aortic dissection/aneurysm, liver perfusion, aortic coarctation, the esophagus, the zebrafish circulation, …), an improved diagnosis (e.g. better ways to measure arterial stiffness; shear wave elastography; system identification methods, … ) and treatment (e.g. patient-specific computational simulation of aortic stent graft placement). Our research tools range from in vivo data measured in patients and in animals models over hydraulic bench experiments to advanced computer models of fluid flow, tissue mechanics, or fluid-structure interaction. The research focus of Patrick Segers involves modelling and simulation of the hemodynamics and mechanics of the
cardiovascular system making use of computer and experimental models, yet always in close collaboration with clinicians and with attention for validation and implementation of new techniques in a clinical setting. Over the past few years, research focused on biomechanics of aortic aneurysms, phenotyping large artery stiffness and function and arterial hemodynamics, and the use of advanced computational tools for medical applications.
Research team
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Full-time professors
Patrick Segers (cardiovascular (biofluid) mechanics and physiology)
Pascal Verdonck (medical devices) -
Part-time ZAP and postdocs
Charlotte Debbaut (biofluid dynamics; (artificial) organs) -
Visiting professors
Nele Famaey (KU Leuven; soft tissue biomechanics)
Malcolm Forward (UZ Gent; musculo-skeletal biomechanics; gait analysis)
Biography
Key publications:
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Lacolley, P., Regnault, V., Segers, P., Laurent, S. Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease. Physiological Reviews. 2017. American Physiological Society. 97 (4) p.1555-1617.
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Chirinos JA, Kips JG, Jacobs DR, Brumback L, Duprez DA, Kronmal R, Bluemke DA, Townsend RR, Vermeersch S, Segers P. Arterial Wave Reflections and Incident Cardiovascular Events and Heart Failure: MESA (Multiethnic Study of Atherosclerosis). Journal of The American College of Cardiology 2012; 60(21): 2170-2177.
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Segers P, Rietzschel ER, De Buyzere ML, Vermeersch SJ, De Bacquer D, Van Bortel LM, et al. Noninvasive (Input) Impedance, Pulse Wave Velocity, and Wave Reflection in Healthy Middle-Aged Men and Women. Hypertension 2007; 49:1248-1255.
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Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors : 'establishing normal and reference values'. European Heart Journal 2010, 31(19) 2338-2350.
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Mortier, P., Holzapfel, G.A., De Beule, M., Van Loo, D., Taeymans, Y., Segers, P., Verdonck, P. & Verhegghe, B.. A novel simulation strategy for stent insertion and deployment in curved coronary bifurcations : comparison of three drug-eluting stents. Annals of Biomedical Engineering 2010, 38(1) 88-99.
Contact & links:
Patrick Segers
Ghent University – campus UZ Gent
IBiTech-bioMMeda
5-Blok B
C. Heymanslaan 10
9000 Gent.
